A small glass (shot glass) full of liquid is shown to the audience. They can inspect it thoroughly, if they so choose. Holding the glass in an outstretched hand which is otherwise empty, the magician then promptly vanishes the glass - liquid and all - by squeezing his palms together. One minute the glass is there, the next it's gone.
This is so good that a famous magic company built their business selling this one trick. No spills- it's self contained.